Transthoracic echocardiography was performed using a Vivid 7 (GE Medical Systems, Horten, Norway) echocardiography machine. Aortic diameter was measured from the parasternal long-axis view at the sinuses of Valsalva (SoV) and at the widest level of the ascending aorta (AoA). All measurements were made in end-diastole and considered the inner edge-to-inner edge distance from the parasternal long-axis view. Measurements were made in M-mode after verifying correct positioning and alignment in the two-dimensional image. For analysis of aortic distensibility, the maximal systolic diameter was measured in M-mode at the same level in the ascending aorta. The average of three measurements in different cardiac cycles was calculated. Diameters were indexed to age, sex and body surface are. Aortic distensibility was calculated as (AoAmax–AoAmin)/(AoAmin × PP), where AoAmax is the ascending aortic diameter in systole, AoAmin is the ascending aortic diameter in diastole, and PP is the pulse pressure (systole minus diastole) calculated from the blood pressure measured in the left arm at the end of the echocardiographic examination. All examinations were performed by one of two sonographers, then reviewed and analyzed offline by one experienced investigator. Data published by Mirea et al. were used as reference echocardiographic diameters [ 12]. Magnetic resonance imaging (MRI) No known pathological sequence variants were identified in the FBN1, COL3A1, TGFBR1, TGFBR2, or ACTA2 in affected individuals. When we filtered variants that were present in all three exome-sequenced afflicted individuals (II:2, II:3, and II:8) but absent from the >1000 exomes present in our local database, we identified sequence variants in SEMA4A, PLCZ1, FBLN5, SPG11, and RANBP2. None of these genes have been previously associated with FTAAD. The gene encoding fibulin 5 ( FBLN5) contributes elastogenesis and vascular development and it is highly expressed in developing arteries [ 19]. We therefore performed segregation analysis for the FBLN5 sequence variant in multiple affected family members, but found no co-segregation with the familial disease. Most Mylk does in fact contain less calories than Cows milk and is almost always lower in saturated fats. Yet many wrongly estimate the amount of health benefits in mylk and expect to reap all the benefits that almonds or oats contain in their raw form. May 29, 2018: MYLK released her debut Monstercat single, Haiku. The song is featured on Monstercat Instinct Vol. 1.

Now more and more people are starting to ditch dairy as it is being vilified for its fat content and the perception that it can cause bloating. Varien • Veeshy • VESK GREEN • Vicetone • Vince Forwards • Vindata • Vintage & Morelli • Vitodito • Vluarr • Volant A variant on one allele of this gene can cause the disease, and imprinting has not been implicated. Individuals carrying this deletion in MYLK have a high risk of presenting with an acute aortic dissection or rupture. Aortic events occur over a wide range of ages and are not always preceded by obvious aortic dilatation. Aortic elastic properties do not differ between carriers and non-carriers of this mutation, rendering it uncertain whether and when carriers should undergo elective prophylactic surgery. Wang L, Guo DC, Cao J, Gong L, Kamm KE, Regalado E, et al. Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet. 2010;87:701–7.

But continuing to consume milk on a regular basis (after infancy) becomes problematic. This is what a majority of Americans do now! Not only that, but we drink this hormonal fluid from a whole different species (mostly cow, sometimes goat, never dog/possum/or pig though!) Why Decrease Dairy for health? Lactose Intolerance There are countless studies connecting saturated fat to CVD, so much so that the American Heart Association recommends cutting down on saturated fat laden foods for no more than 5% calories coming from saturated fat Two individuals (II:2 and II:3) survived a type A dissection and underwent emergency surgery to place conduits in their ascending aorta. They were both carriers of the MYLK deletion. Unsweetned Fortified Soy Mylk is one of two mylk substitutes that should be used for toddlers who are dependent on it (rather than 100% from food) for fat/calories/protein/vit D and Calcium. In a large consanguineous Arab family with thoracic aortic aneurysm and dissection, Shalata et al. (2018) identified a missense mutation in the MYLK gene (A1491S; 600922.0005) that was not found in ethnically matched controls or public variant databases. The mutation was present in homozygosity in 6 severely affected family members and in heterozygosity in 3 patients with a later age of onset; the mutation was also present in heterozygosity in 16 asymptomatic family members. The authors stated that the most appropriate designation for the mode of inheritance in this family was autosomal dominant with incomplete penetrance. Comprehensive medical history and clinical data analysis of homozygous individuals excluded congenital bladder or intestine involvement; there was thus no evidence for megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS; see below) in this family.

Mylk is plant-based and ranges from the popular soya, coconut, almond, cashew and oat mylk to newer varieties such as hemp, pea, walnut, quinoa, rice, spelt, hazelnut and even tiger nut mylk. Mylk is directly referring to plant-based milk alternatives (oat, almond, soy, rice, coconut, etc.) Instead of having to say non-dairy milk, we can simply refer to it as mylk! No one of the carriers had experienced abnormal bleeding or wound healing after minor operations. Their surgical scars appeared normal. None of the women described bleeding or other problems during the pregnancy, delivery or post partum. There were no common symptoms from the gastrointestinal tract, urinary tract or circulatory system. No musculoskeletal, joint, or eye symptoms were evident. Four carriers have bronchial asthma, one has persistent atrial fibrillation and one has osteoarthrosis of the wrists.

If you’d like to go beyond basic mylk, you can add a number of flavors as you blend. Maple syrup and agave nectar add natural sweetener, and vanilla extract or cinnamon can turn your mylk into a coffee creamer.

Hadar Adora • Haley • Haley Reinhart • Hannah Sumner • Harry Brooks JNR • Harry Shotta • Hauskey • Heleen • Helen • Helen Tess • Hight • HOLLY • Hugo Allen Investigation of the genetic basis of thoracic aortic aneurysms and dissections has yielded an increased understanding of the underlying genetic changes that are associated with significantly increased risk. Much of the current literature describes syndromic causes of heritable thoracic aortic disease (HTAD), including Marfan syndrome, Loeys–Dietz syndrome and vascular Ehlers–Danlos syndrome. In recent years, pathogenic variants (PV) of HTAD genes that cause aortic disease with no other syndromic findings have been identified, such as ACTA2 PV, which are responsible for up to 20% of families with non-syndromic HTAD, 1, 2 and PV of MYLK, PRKG1, and MYH11. 3, 4, 5 Haen • Hairitage • Hammerhead • Haneri • Harvey • Haus of Panda • hayve • Heard Right • Heartful • Heever • Hex Cougar • Hiski • Holly • Holly Drummond • Holochrome • Honey & Badger • Hope 6 • Hot Date! • HVDES

Rachel Hirons • Ragga Twins • Ralph Larenzo • Raycee Jones • Raymond Revel • Reija Lee • Remus • Richard Judge • Rico Nasty • Roufaida • Royal • Royal Sapien • Rue Melo • RYNN Sally Jay • Sam Tabor • Sara Skinner • Sarah Clark • Savage • Savoi • Saysha • Sebastian • Sebastian Lind • Seri • Shantee • Siera • Simon Latham • Sivan • SJMA Choir • SKYXXX • Slyleaf • Sofia Quinn • Sonam • Sophie Strauss • Sophiya • Spencer Ludwig • Stefan Ludik • Stella Talpo • Sundial • SYKES • Syrin • Syon Cashews are known to contain a lot of fats- while this sounds negative at first, they are actually full of healthy fats! With polyunsaturated and monounsaturated fats in high amounts, cashews are considered a heart-healthy food, lowering the risk of heart disease and helping to balance your cholesterol. In addition to that, cashew MYLK is full of vitamins like vitamin D and B, as well as minerals like zinc, magnesium, copper, calcium, potassium, and zinc. The first thing you will want to do is soak your cashews overnight in a bowl of cold water; if you’re pressed for time, 4 hours or more in warm water would be enough, but 8-10 hours is best. The ratio doesn’t matter here, as the water will be drained: it should just be enough to cover the cashews. Cross-sectional lumen areas of the ascending aorta were determined throughout the cardiac cycle using a semi-automated contouring method (Segment® v1.9, MedViso, Lund, Sweden) at the level of pulmonary bifurcation and edited when needed [ 14]. All tracings were reviewed and edited by one observer. Systolic and diastolic arterial blood pressures were measured in the beginning of the flow sequences. Aortic distensibility was calculated with the formula D = (AoAmax–AoAmin)/(AoAmin × PP), where AoAmax is the largest area in ascending aorta (systole), AoAmin is the smallest area (diastole) and PP is the pulse pressure. Arterial stiffness