If you can tolerate Deadpool's demented humor, you'll find a nice few hours of entertainment within the game". It is unknown how Activision reacquired the rights to re-publish Deadpool, but it is believed that the re-release was timed to help promote the then-upcoming Deadpool feature film, released a few months after the next-gen version of the game. Edge said, "while we'll accept that Deadpool the character is an acquired taste, this is an indisputably poor game, one whose knowing winks and quips come off not as metacommentary but as tacit apologia for its litany of specific failings".

That's okay, bearing in mind there are better games in which you slice people up for points, and that everything Deadpool the man revels in – the bullets, the blood and the babes – are sincerely sought and embarrassingly commonplace in the marketplace to begin with. Several sites wrote positive impressions of the demo that was shown at Gamescom and the Electronic Entertainment Expo (E3), including Joystiq and GameSpot. Summary Deadpool speaks: "There are a few important things I need to say before you crack into my insanely sweet game.Of course, the action is as standard as can be and often done better, but the sense of humor is so perfect, that you'll actually suspect Deadpool himself to have developed the game. Two new maps are also added, the GRT Plaza and Inside the Tower to Deadpool Challenge mode, and also two bonus costumes, the D-Pooly and Uncanny X-Force suits only for use in the unlockable Infinite mode where stats are tracked on a global leaderboard. As the credits roll, Deadpool is thrilled with how great his game is and talks to High Moon's representative Peter Della Penna, who admits that he did not really blow their budget. While we’ll accept that Deadpool the character is an acquired taste, this is an indisputably poor game, one whose knowing winks and quips come off not as metacommentary but as tacit apologia for its litany of specific failings.

Upon release, the game received mixed reviews, being praised for its humor and plot elements while being critiqued for deficiencies in its gameplay. Digital Spy said it was "far from a bad game, yet the developers' over-reliance on the appeal of the source material means it rarely shoots for the stars".

This game I was looking forward to for a very long time, But when I saw the game play I was very put off. Better to take it as an unvarnished comedy, then, because Deadpool self-destructs when you read so deeply (and madly? They appreciated its unique fourth-wall breaking gameplay sequences, but said that "Unfortunately, those points are few and far between. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Joining them, Deadpool flies the Blackbird to Genosha, Sinister's hideout, but crashes the plane, leaving the X-Men unconscious.