Electron-transport Chains Enabled Anaerobic Bacteria to Use Nonfermentable Molecules as Their Major Source of Energy For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). Microsurgery and Genetics Reveal the Logic of Developmental Control; Gene Cloning and Sequencing Reveal Its Molecular Mechanisms Some Key Regulatory Genes Define a Cell Type; Others Can Activate the Program for Creation of an Entire Organ Most Membrane-enclosed Organelles Cannot Be Constructed From Scratch: They Require Information in the Organelle Itself

Noncovalent Bonds Specify Both the Precise Shape of a Macromolecule and its Binding to Other MoleculesWhen Activated by Antigen, a B Cell Switches From Making a Membrane-Bound Antibody to Making a Secreted Form of the Same Antibody

By Providing an Inexhaustible Source of Reducing Power, Photosynthetic Bacteria Overcame a Major Evolutionary Obstacle Authors: Bruce Albert, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter An Asymmetric Distribution of Carrier Proteins in Epithelial Cells Underlies the Transcellular Transport of Solutes Ideal for libraries, laboratories, and researchers, this Reference Edition of Molecular Biology of the Cell, Fifth Edition offers an alternative to the student version by providing the complete text of Chapters 1-25 in printed format.*

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. Extracellular Signals Are Greatly Amplified by the Use of Small Intracellular Mediators and Enzymatic Cascades Ca 2+/Calmodulin-dependent Protein Kinases (CaM-Kinases) Mediate Many of the Actions of Ca 2+ in Animal Cells The Photosynthetic Electron-transport Chains of Cyanobacteria Produced Atmospheric Oxygen and Permitted New Life-Forms Comparisons Between the DNAs of Related Organisms Distinguish Conserved and Nonconserved Regions of DNA Sequence

Initial Patterns Are Established in Small Fields of Cells and Refined by Sequential Induction as the Embryo Grows A Special Nucleotide-Polymerizing Enzyme Synthesizes Short RNA Primer Molecules on the Lagging Strand A Strand-directed Mismatch Repair System Removes Replication Errors That Escape from the Replication Machine

Contents

Neuromuscular Transmission Involves the Sequential Activation of Five Different Sets of Ion Channels The phases of the cell cycle. The cell grows continuously in interphase, which consists of three phases: DNA replication is confined to S phase; G 1 is the gap between M phase and S phase, while G 2 is the gap between S phase and M phase. In M phase, the (more...)