j. The dark-pigmented colonies (H 2S-producing organisms) were counted as whole plate counts by hand under appropriate magnification or by Segment counts using a Spiral Biotech counting template. the inventors believe that the efficacy of the essential oils is enhanced by the creation of a layer of pullulan in the oral cavity that holds the essential oils. Also useful are artificial, natural or synthetic fruit flavors such as vanilla, chocolate, coffee, cocoa and citrus oil, including lemon! Although gums and lozenges have been formulated to achieve a variety of beneficial effects, they are not always socially acceptable.

Generally, any flavoring or food additive, such as those described in Chemicals Used in Food Processing, publication 1274 by the National Academy of Sciences, pages 63-258, may be used.This, he said, was supposed to be either green apple or watermelon, though he couldn’t remember which until he put it in his mouth. triglycerides include vegetable oils such as corn oil, sunflower oil, peanut oil, olive oil, canola oil, soybean oil and mixtures thereof. It has been proposed to use an edible film as a vehicle for unobtrusively delivering breath-freshening agents. Other molecules like sildenafil citrate, tadalafil, methylcobalamin and vitamin D 3 are also developed by IntelGenx Zim Laboratories Ltd.

Gums and mints are used over extended periods of time, and they require an amount of sucking or chewing action on the part of the consumer, which can be distracting, tedious and undesirable.Since then, thin-film products for other breath fresheners, as well as a number of cold, flu, anti-snoring and gastrointestinal medications, have entered the marketplace. Example 1 produced a film according to the invention having a blue-green tint, a mint odor and a refreshing mint taste. WO 98/26780 discloses a flat, foil, paper or wafer type presentation for the application and release of active substances in the buccal cavity. Our alcohol-free, specially formulated mouthwash effectively fights germs, reduces plaque, and freshens breath, promoting overall oral health.

Since the size of the dosage form has limitation, high-dose molecules are difficult to be incorporated in OS. Pseudoephedrine ("soo-doe-eh-fed-reen") is a common ingredient in cold medicines such as Sudafed, Wal-Phed, CVS Nasal Decongestant, and others.

Commonly used flavors include mints such as peppermint, artificial vanilla, cinnamon derivatives, and various fruit flavors, whether employed individually or in admixture. The US and New Zealand are the only two developed countries that allow drug companies to advertise prescription medicines directly to the public. A61K8/817— Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.

The inventors have discovered how to provide a high oil content film that is moist enough so that it is not brittle, but is not so moist that it feels undesirably slimy or significantly adheres to adjacent films.C. dipeptide based sweeteners such as L-aspartic acid derived sweeteners, such as L-aspartyl-L-phenylalanine methyl ester (aspartame) and materials described in U.