An overdose of paracetamol is dangerous and capable of causing serious damage to the liver and kidneys. You should never exceed the dose stated in the information leaflet supplied with this medicine. Immediate medical advice should be sought in the event of an overdose with this medicine, even if you feel well, because of the risk of delayed, serious liver damage. There are limited data on the use of guaifenesin in pregnant women. Guaifenesin has been linked with an increased risk of neural tube defects in a small number of women with febrile illness in the first trimester of pregnancy. As part of our latest baby survey, we quizzed parents on which brand of infant pain relief they'd bought for their child or children in the past year. Additional symptoms may include hypertension, and possibly reflex bradycardia. In severe cases confusion, seizures and arrhythmias may occur. However the amount required to produce serious phenylephrine toxicity would be greater than that required to cause paracetamol-related liver toxicity.

It costs around 33p per dose of one 250mg tablet for children aged six to nine, double that (66p per dose of two tablets) for nine to 12-year-olds and even treble that for 12 to 16-year-olds (99p per dose of three tablets).It is thought paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). The paracetamol in Lemsip max sinus sachets helps relieve aches, pains, sore throats and fever associated with colds and flu. Adverse effects of paracetamol are rare.Very rare cases of serious skin reactions have been reported. Very rarely hypersensitivity and anaphylatic reactions including skin rash may occur. There have been reports of blood dyscrasias including thrombocytopenia and agranulocytosis but these were not necessarily causally related to paracetamol. Symptoms of paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. If you're taking medicines for high blood pressure you shouldn't take Lemsip cold & flu sachets, because the decongestant may make your blood pressure medicine less effective. Other medicine interactions for Lemsip cold & flu related to paracetamol

Swallow paracetamol tablets or capsules with a drink of water. You can take it with or without food. Syrup Do not give more medicine than the label tells you to. If your child does not get better, talk to your doctor. kg as a single dose. Then 10mg/kg to 15mg/kg every 8 to 12 hours when necessary, up to a maximum of 30mg/kg daily in divided doses. AdministrationSorbitol and maltitol may cause gastrointestinal discomfort and have a mild laxative effect. Each 5 ml spoonful of this product contains 0.97g sorbitol liquid and 2.72g of maltitol liquid. Calorific values: 2.6 kcal/g sorbitol and 2.3 kcal/g maltitol. There are currently no other medicines available in the UK that contain this combination of active ingredients. This medicine contains 14.32mg propylene glycol (E1520) in each 5ml dose, which is equivalent to 2.86mg/ml. Caution in babies less than 4 weeks old. Co-administration with any substrate for alcohol dehydrogenase such as ethanol may induce serious adverse effects in neonates. Phenylephrine overdose is likely to result in: nervousness, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, reflex bradycardia, mydriasis, acute angle closure glaucoma (most likely to occur in those with closed angle glaucoma), tachycardia, palpitations, allergic reactions (e.g. rash, urticaria, allergic dermatitis), dysuria, urinary retention (most likely to occur in those with bladder outlet obstruction, such as prostatic hypertrophy). Alcohol increases the risk of liver damage that can occur if an overdose of paracetamol is taken. The hazards of paracetamol overdose are greater in persistant heavy drinkers and in people with alcoholic liver disease.

https://www.mhra.gov.uk/Howweregulate/Medicines/Licensingofmedicines/Informationforlicenceapplicants/Guidance/OverdosesectionsofSPCs/Genericoverdosesections/Paracetamol/index.htm Nephrotoxicity following therapeutic doses of paracetamol is uncommon, but papillary necrosis has been reported after prolonged administration. Calpol advises adults and children over the age of 16 to try Calpol SixPlus (suitable from six years). It contains paracetamol and is used to help with fever, colds, earache, sore throats and general pains. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with Resolve. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. Paracetamol is excreted in breast milk but not in a clinically significant amount. Available published data do not contraindicate breastfeeding.Paracetamol has been found to be non-mutagenic in bacterial mutagenicity assays, although a clear clastogenic effect has been observed in mammalian cells in vitro following exposure to paracetamol (3 and 10 mM for 2h). Use during breastfeeding should be avoided, unless recommended by a healthcare professional (see section 4.6). Do not give this medicine to your child for more than 3 days without speaking to your doctor or pharmacist. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.